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Vol. 110. Num. 1.January - February 2019
Pages e1-e6Pages 1-86
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Vol. 110. Num. 1.January - February 2019
Pages e1-e6Pages 1-86
Novelties in Dermatology
DOI: 10.1016/j.adengl.2018.05.035
Psoriasis and Depression: The Role of Inflammation
Psoriasis y depresión: el papel de la inflamación
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S. González-Parraa,
Corresponding author
sgparra@salud.madrid.org

Corresponding author.
, E. Daudénb
a Servicio de Psiquiatría, Hospital Doctor Rodríguez Lafora, Madrid, Spain
b Servicio de Dermatología, Hospital Universitario de La Princesa, Madrid, Spain
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Figures (2)
Tables (4)
Table 1. Factors Associated with Increased Risk of Inflammation That Could Indirectly Facilitate the Detection of the Inflammatory Phenotype.
Table 2. Healthy Habits That Reduce Inflammation and the Risk of Depression.
Table 3. Impact of Biologic Therapy in Psoriasis Measured Using the Dermatology Life Quality Index (DLQI).
Table 4. Studies on the Influence of Tumor Necrosis Factor Inhibitors (TNFi) on Comorbid Depressive Symptoms.
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Abstract

Psoriasis is a chronic, systemic inflammatory disorder with multiple comorbidities.

The most common comorbidities are mental disorders, especially depression, which can interact negatively with psoriasis to produce a dangerous vicious circle. Depression in psoriasis has traditionally been explained as a response to psychosocial factors and impaired quality of life.

However, a new hypothesis linking depression and psoriasis through chronic inflammation offers insights that should help us to understand and treat these diseases. In this approach, new drugs and lifestyle have an important role.

Keywords:
Depression
Psoriasis
Inflammation
Resumen

La psoriasis es un proceso inflamatorio crónico y sistémico con múltiples comorbilidades. Entre las más frecuentes se encuentran las enfermedades mentales y en especial la depresión, con la que interrelacionan negativamente llegando a producir un peligroso círculo vicioso. Clásicamente se ha explicado la depresión de los pacientes con psoriasis como reactiva a factores psicosociales y el deterioro en la calidad de vida. Sin embargo, la asociación de estas dos patologías a través del proceso inflamatorio crónico ofrece una nueva hipótesis para su comprensión y tratamiento. Este enfoque incide en nuevos fármacos y la importancia del estilo de vida.

Palabras clave:
Depresión
Psoriasis
Inflamación

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